Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, ...

Genes exist in most cells. Inside a cell is a long strand of the chemical DNA (deoxyribonucleic acid). A DNA sequence is a specific lineup of chemical base pairs along its strand. The part of DNA ...

A double-strand DNA break (DSB) occurs or arises when both strands of the DNA duplex are severed, often as the result of ionizing radiation. They are particularly deleterious as the DNA ends can ...

Watson and Crick showed that each strand of the DNA molecule was a template for the other. During cell division the two strands separate and on each strand a new "other half" is built, just like ...

Trends in Genetics 22, 46–55 (2006). Argueso, J. L. et al. Double-strand breaks associated with repetitive DNA can reshape the genome. Proceedings of the Naitonal Academy of Sciences 105 ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted upon by an enzyme called RNA polymerase. This is a molecular machine which ...

The true identity of Jack the Ripper, whose grisly murders terrorized east London in 1888, has been a mystery ever since.

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...