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Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits.

Cell cycle events are controlled tightly by several kinase families including CDKs, Plks, and Aurora kinases. What is interesting about these kinases is that they don't always act alone.

Provided herein are novel bicyclic amines as CDK2 inhibitors, pharmaceutical compositions, use of such compounds in treating metastatic breast cancer or metastatic lung cancer and processes for ...

It has been over 40 years since the cell division cycle (cdc) mutants were first described and more than 30 years since molecular characterization of cyclins and cyclin-dependent kinases (Cdks) was ...