为了解决上述难题，研究人员开始尝试通过非病毒纳米载体在体内原位制备CAR-M细胞，直接治疗实体瘤。此外，目前对巨噬细胞的胞内域（ICD）的结构研究主要集中在CD3ζ信号转导上。然而，仅仅依赖CD3ζ并不能完全发挥巨噬细胞的多功能特性，用于肿瘤免疫疗法。

Engineered immune cells called CAR Ts that can seek out and destroy B cells have transformed the treatment of some blood cancers, and are raising hopes for possible cures for autoimmune diseases.

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