Elevated levels of conjugated bilirubin in the serum and abnormal retention of bromsulfalein distinguish the syndrome described above from Gilbert's disease. Only unconjugated bilirubin is ...

Background: “Kernicterus” historically describes the unconjugated bilirubin (UCB) accumulation in selective brain regions, leading to neurological damage in hyperbilirubinemic newborn babies ...

Neonatal intestines contain beta-glucuronidase, an enzyme capable of reducing bilirubin back to the unconjugated state by hydrolysis of the bilirubin glucuronide(s). Unconjugated bilirubin can be ...