A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription into RNA – the first step of the process by which an organism ...

Cell proteins called linker histones were discovered in the late 1800s. They have been known to influence genetic expression by, for example, providing structure, organization and folding of DNA, but ...

Cell proteins called linker histones were discovered in the late 1800s. They have been known to influence genetic expression by, for example, providing structure, organization and folding of DNA ...

Bristol Myers Squibb Co. has synthesized proteolysis targeting chimera (PROTAC) compounds comprising a cereblon (CRBN) E3 ubiquitin ligase-binding moiety coupled to a DNA-binding protein Ikaros (IKZF1 ...