RNA repair enzymes capable of sealing 2’,3’-cyclic-PO 4 /5’-OH breaks or 3’-OH/5’-PO 4 breaks are present in diverse taxa in all phylogenetic domains of life. ATP-dependent RNA ligases join 3’-OH and ...

The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

But the enzyme they were using, biotin ligase, was too specific for its small-molecule substrate, biotin, even after active-site mutagenesis. In a literature search, they came across a ...

“Using our new ligase enzymes we can produce peptides with promising anti-cancer activity in a single process with excellent yields. Previously, these types of peptides were produced in much lower ...

Ubiquitylation requires the subsequent actions of three enzymes: an activating E1, a conjugating E2 and an E3 ligase. Hoeller et al. now show that monoubiquitylation of ubiquitin-binding domain ...

Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to ...

During ubiquitination, a group of enzymes called E3 ubiquitin ligases attach a small protein called ubiquitin to other proteins. This tagging, in turn, helps determine the fate of the targeted ...

Nurix has built an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug ...