"Our data highlights the role of RNA alternative splicing in impacting glioma malignance and heterogeneity and its ... that targeting PTBP1 in glioma cells results in the generation of numerous ...

Current therapeutic approaches of GBM face a number of challenges including (I) the GBM highly infiltrative nature, rendering impossible its complete surgical resection; (II) its intratumoral ...

It enabled us to develop precise single-copy transgenesis to generate murine gliomas which highly mimic the human diseases. Here we aimed to do and “apples-to-apples” characterization of the internal ...