Within the group of patients with musculoskeletal disease, 9,642 patients with gout (3,890 women) were compared with 48,230 controls (19,450 women), matched for age and sex, for the incidence of ...

Two gout experts debated whether first-line urate-lowering therapy should consist of a xanthine oxidase inhibitor or should instead be tailored to the mechanism of a patient’s hyperuricemia.

Inflammatory arthritis in patients with gout can usually be treated with drugs that counter hyperuricemia. Treatment fails in some patients, however, so a second-line therapy is desirable.

About Hyperuricemia, Gout and Health Consequences The breakdown of nucleotides in the blood occurs through purine metabolism and results in the formation of uric acid by the xanthine oxidase enzyme.

While kidneys usually flush it out, but too much of it can stay in blood and cause a condition called hyperuricemia. The ...