Hypoxia enhances proliferation, angiogenesis, metastasis, chemoresistance, and radioresistance of hepatocellular carcinoma (HCC); suppresses differentiation and apoptosis of HCC; and consequently ...

It seems that proteins called hypoxia-inducible factors (HIFs ... including various genes involved in glucose metabolism, angiogenesis, cell division, and cell death. Many of the genes repressed ...

Central to this resistance is angiogenesis—the abnormal formation of blood vessels within tumors. These newly formed vessels exacerbate tumor hypoxia and obstruct the delivery of therapeutic ...

Central to this resistance is angiogenesis—the abnormal formation of blood vessels within tumors. These newly formed vessels exacerbate tumor hypoxia and obstruct the delivery of therapeutic ...

Van Meir's research examines how genetic alterations and hypoxia induce changes in cell biology that promote tumor formation with particular emphasis on heterotypic cell-cell signaling, including ...

Yet, therapeutic resistance, hypoxia-induced angiogenesis, and immune evasion remain significant barriers. The advent of T-cell receptor (TCR) sequencing offers a transformative lens to unravel ...