This manuscript offers valuable insights by identifying two distinct liver cancer subtypes through multi-omics integration and developing a robust prognostic model, validated across various datasets, ...

Reply to: Concerns on Potential Risk of Roxadustat in Promoting Tumor Progression: Double-Edged Sword of Hypoxia-Inducible Factor-1α Activation The following represents disclosure information provided ...

and co-live in the metabolically harsh tumor-microenvironments characterized by hypoxia and poor nutrition, placing them in a fierce metabolic tug-of-war," Shi said. "How to tilt this metabolic ...

Despite recent therapeutic breakthroughs, cancer patients continue to face high recurrence and mortality rates due to treatment resistance. Cancer stem cells (CSCs), a subpopulation with self-renewal ...

Tumor hypoxia is known to be associated with a reduction in radio-response. [85,86] The EORTC is now planning a randomized Phase III study [107] in patients with locally advanced HPV/p16-negative ...

These newly formed vessels exacerbate tumor hypoxia and obstruct the delivery of therapeutic agents, complicating treatment efforts. Understanding how angiogenesis contributes to drug resistance ...