When they compared the genes in the hypoxia-response signature of normal cells to that of different cancer cells, they found that they were able to classify different tumors by their hypoxia response.

and co-live in the metabolically harsh tumor-microenvironments characterized by hypoxia and poor nutrition, placing them in a fierce metabolic tug-of-war," Shi said. "How to tilt this metabolic ...

These newly formed vessels exacerbate tumor hypoxia and obstruct the delivery of therapeutic agents, complicating treatment efforts. Understanding how angiogenesis contributes to drug resistance ...

or hypoxia, cells trigger a cascade of physiological events to restore oxygen concentrations. The question was how. In 2019, William Kaelin Jr., MD, from the Dana-Farber Cancer Institute and ...

Tumor hypoxia is known to be associated with a reduction in radio-response. [85,86] The EORTC is now planning a randomized Phase III study [107] in patients with locally advanced HPV/p16-negative ...

Reply to: Concerns on Potential Risk of Roxadustat in Promoting Tumor Progression: Double-Edged Sword of Hypoxia-Inducible Factor-1α Activation The following represents disclosure information provided ...