Since the application of molecular biology in cancer biology, lung cancer research has classically focused on molecular drivers of disease. One such pathway, the hypoxic response pathway, is ...

JG Foster is supported by Cancer Research UK (CRUK projectgrant 12733). The hypoxia research within the group of TVS is supported by the Biotechnology and Biological Sciences Research Council ...

HIF1α identified as key regulator that induces cancer-killing ability of hypoxic T cells, playing a role in ICB resistance.

de la Calle-Fabregat, C., et al. (2024) NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the ...

The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen ... “However, it has been unknown, under hypoxia, whether and how HIF1α regulates IFN-γ induction and glycolysis ...

The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen ... how HIF1α in T cells is key for induction of interferon gamma, or IFN-γ, in that hypoxic environment. The cytokine ...

Yet any potential intervention has to take place under unusual conditions -- the cancer microenvironment nearly ... or IFN-γ, in that hypoxic environment. The cytokine IFN-γ is known to be ...

The tumor microenvironment (TME) refers to the cells ... Immune checkpoint inhibitors rescue T cell activity by blocking surface proteins responsible for dysregulation. In addition, the TME is highly ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

Yet any potential intervention has to take place under unusual conditions—the cancer microenvironment nearly ... or IFN-γ, in that hypoxic environment. The cytokine IFN-γ is known to be ...