For example, the researchers used CRISPR-Cas 9 to knock out the leptin receptor (LEPR) in these BNC2 neurons. Those mice ate more and gained more weight than control mice. In addition, researchers ...

Although previous research has shown that the hormone leptin acts directly on hunger neurons through leptin receptors to promote the development of neural circuitry, results that will be published in ...

Mice fed a high-fat diet produce an enzyme named MMP-2 that clips receptors for the hormone leptin from the surface of neuronal cells in the hypothalamus. This blocks leptin from binding to its ...