12 月 11 日，中国科学技术大学生命科学与医学部、免疫应答与免疫治疗重点实验室王毅课题组在 Cell Reports Physical Science 在线发表了一篇题为“ A heparanase-specific LYTAC degrader reinforces natural killer cell cytotoxicity within tumor microenvironment ...

However, NK cells in the tumor microenvironment often become functionally exhausted, characterized by decreased numbers and impaired functions due to imbalances in immune regulatory signals.

Following the discovery of inhibitory KIR and the understanding that they play a role in preventing NK cell killing of self MHC I-expressing tumor cells, investigators began to research the ...

The interactions between cells in the tumor microenvironment (TME) are critical to tumor initiation, progression, metastasis and therapeutic responses. As a key target in cancer research and ...

The immune system plays a pivotal role in colorectal cancer (CRC), with immune cells such as T cells, natural killer (NK) cells, macrophages, and dendritic ...

The following is a summary of “myCAF-derived exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine ...

This manuscript offers valuable insights by identifying two distinct liver cancer subtypes through multi-omics integration and developing a robust prognostic model, validated across various datasets, ...

Breast cancer cells exhibit organotropism during metastasis, showing preferential homing to certain organs such as bone, lung, liver, and brain. One potential explanation for this organotropic ...

Bemarituzumab is under clinical development by Amgen and currently in Phase III for Bladder Cancer. According to GlobalData, Phase III drugs for Bladder Cancer have a 47% phase transition success rate ...

Selvascan is a biotech startup developing an immune cancer therapy based on natural killer (NK) cells, which are innate immune cells. It was established in October 2023, based on the research ...