One, the agouti-related protein (AGRP) and neuropeptide Y (NPY) neurons, stimulates hunger, while the other, pro-opiomelanocortin (POMC) neurons, curbs it. This delicate balance orchestrates ...
Conflicting effects of nicotine on the major orexigenic peptide, neuropeptide Y (NPY), have been observed in the brain, but the effects of smoking are unknown. Thus, we aimed to investigate how ...
Within the ARC, there are orexigenic coexpressing neuropeptide Y/Agouti gene-related protein (NPY/AgRP) and anorexigenic pro-opiomelanocortin (POMC)/cocaine- and amphetamine-related transcript ...
Both teams used leptin-deficient mice (ob/ob) and investigated the effect of leptin on two distinct populations of neurons in the hypothalamic arcuate nucleus—one producing the appetite-stimulating ...
[34–36] From the ARC, these first-order POMC/CART and NPY/AgRP neurons project to second-order neurons in several hypothalamic nuclei, including the VMN, DMN, PVN and the lateral hypothalamic area.
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