Charged nanoparticles can alter the local physical properties of lipid membranes, which could shed new light on the interactions between living cells and nanomaterials. An emerging 'rule of thumb ...

Lipid nanoparticles (LNPs) transport small molecules into the body. The most well-known LNP cargo is mRNA, the key constituent of some of the early vaccines against COVID-19. But that is just one ...

Function-engineerable nanoparticles in combination with the advantageous effects of various functional lipid components enable achievement of enhanced blood stability, decreased toxicity and ...

Lipid nanoparticles (LNPs) are primed to revolutionize the development of nucleic acid therapies. The trusted lipid experts at Cayman Chemical provide industry-leading solutions for every stage of LNP ...

Consists of cationic lipid AtuFECT01, neutral helper lipid 1,2-diphytanoyl-sn-glycero-3-phosphoethanolamine, and PEGylated lipid ... Intravenous; LNP: Lipid nanoparticle; TTR: Transthyretin.

Get Instant Summarized Text (Gist) Lipid nanoparticles encapsulating mRNA have been successfully delivered to the intestines, bypassing the liver, by altering the lipid composition. This method ...

We used lipid nanoparticles to deliver mRNA and siRNA to human PCa cells to evaluate our technique’s ability to both restore the lost PTEN and silence the overexpressed AR. Our strategy could ...

To create nanoparticles that deliver RNA, Whitehead, professor of chemical engineering and biomedical engineering, uses ...

The development of acid degradable linkers that rapidly hydrolyze at endosomal pHs is a central problem in the field of drug delivery. Acid degradable linkages are challenging to develop because of ...