The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as ...

Charged nanoparticles can alter the local physical properties of lipid membranes, which could shed new light on the interactions between living cells and nanomaterials. An emerging 'rule of thumb ...

Lipid nanoparticles (LNPs) are primed to revolutionize the development of nucleic acid therapies. The trusted lipid experts at Cayman Chemical provide industry-leading solutions for every stage of LNP ...

Genetic medicines could treat certain diseases, however, the current delivery systems available—viral vectors and lipid nanoparticles (LNPs)—pose unique challenges for gene therapy applications. For ...

Consists of cationic lipid AtuFECT01, neutral helper lipid 1,2-diphytanoyl-sn-glycero-3-phosphoethanolamine, and PEGylated lipid ... Intravenous; LNP: Lipid nanoparticle; TTR: Transthyretin.

Get Instant Summarized Text (Gist) Lipid nanoparticles encapsulating mRNA have been successfully delivered to the intestines, bypassing the liver, by altering the lipid composition. This method ...

We used lipid nanoparticles to deliver mRNA and siRNA to human PCa cells to evaluate our technique’s ability to both restore the lost PTEN and silence the overexpressed AR. Our strategy could ...

To create nanoparticles that deliver RNA, Whitehead, professor of chemical engineering and biomedical engineering, uses ...

The POx-based lipid nanoparticles were comparable in transfection capability to their PEGylated counterparts. Also, the prophylactic effect in SARS-CoV-2 vaccination was not compromised versus a ...

Consists of cationic lipid AtuFECT01, neutral helper lipid 1,2-diphytanoyl-sn-glycero-3-phosphoethanolamine, and PEGylated lipid ... Intravenous; LNP: Lipid nanoparticle; TTR: Transthyretin.