Additionally, 5 of the 16 JIA patients without overt macrophage activation syndrome also showed high levels of sIL-2Rα and sCD163. These patients had highly elevated serum ferritin and markers of ...

In the study, significant knockdown of TNF levels by administration of these nanoparticles was first demonstrated in vitro in stimulated peritoneal macrophages isolated from C57BL/6J mice.