Systematically integrate biological contextual information with causal estimates generated using Mendelian randomization Develop novel approaches to identifying, validating and prioritising potential ...

The advantage of this approach is that, unlike in a structural equation model, these interactions do not need to be specified ahead of the test, making it a true discovery method. Although causal ...

A genetic causal link between rheumatoid arthritis (RA) and an increased risk of traumatic and osteoporotic fractures ...