But virtually all other cells have a primary cilium. Likewise, for many years it was generally assumed that the entire phylum Nematoda, comprising roundworms, completely lacked cilia or flagella.
Further, we documented that in each of the five astrocytoma/glioblastoma cell lines studied (U-87 MG, T98G, U-251 MG, U-373 MG, U-138 MG), fully formed primary cilia ...
Recent work linking Hh signalling to sterol metabolites and protein-trafficking events at the primary cilium promises to shed light on the biochemical basis of how Patched inhibits Smoothened ...
which are hair-like structures that perform a variety of functions such as movement for motile cilia and aiding in structure in function for non-motile, or primary, cilia. The primary cilia also act ...
The goal of my research is to understand the biogenesis of centrioles/centrosomes and primary cilia, and how defects in these processes affect mammalian cell physiology and evoke stress responses.
We are investigating the function of these epigenetic modifiers on microtubule and actin dynamics during mitosis and during quiescence, when cells project primary cilia. In particular, our ...