More information: Maria Hatziapostolou et al, Promoter Methylation Leads to Hepatocyte Nuclear Factor 4A Loss and Pancreatic Cancer Aggressiveness, Gastro Hep Advances (2024). DOI: 10.1016/j.gastha.

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

As previously mentioned, DNA methylation occurs at CpG sites, and a majority of CpG cytosines are methylated in mammals. However, there are stretches of DNA near promoter regions that have higher ...

c, The mutational event can be followed by gene silencing through promoter methylation (vertical bars) without LOH. d, Biallelic silencing of both gene copies without LOH or gene mutation.