One of the surprising findings to come out of our mutant screens for molting-defective worms was the identification of several protein kinases, NEKL-2 and NEKL-3. Protein kinases regulate the ...

Capture Compound mass spectrometry (CCMS) is an innovative technology to reduce biological sample complexity by selective isolation of targeted protein or enzyme families. Small synthetic ...

Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits.

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...

Kinases, enzymes that phosphorylate proteins, generally control the amplitude of a signal response, whereas phosphatases, enzymes that dephopshorylate proteins, are thought to be important for ...

Kinases are specialized enzymes that transfer phosphate groups from ATP to a substrate. The most often studied kinases are protein kinases, which are generally subdivided into tyrosine, and ...

Mitosis, the fundamental process by which cells divide, ensures the accurate distribution of genetic material to daughter ...

Our longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate their signaling ...

Our focus is on the Src family tyrosine protein kinases, Hedgehog and Wnt proteins. Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD. Inhibitors of Hedgehog acyltransferase block Sonic ...

My research career has been focused on kinases, enzymatic proteins that control signaling within cells through their phosphorylation of other proteins. Kinases are critically involved in virtually all ...

The scientists found that aPKC zeta and iota—and three other proteins the kinases normally interact and bind with to regulate cell polarity—are repurposed by PDAC cells lacking access to ...

The protein, called Aurora-A, is one of a group of proteins called kinases. Kinases are enzymes which modify their targets to regulate many cell functions; they are commonly dysregulated in ...