lung cancer research has classically focused on molecular drivers of disease. One such pathway, the hypoxic response pathway, is activated by reduced local oxygen concentrations at the tumor site.

These cells inhibit antitumor immunity while increasing tumor growth. The hypoxic response pathway Cells respond to low oxygen levels through stabilization of the HIF1/2α transcription factors.

In a study published in Nature Communications, Lewis Zhichang Shi, M.D., Ph.D., and University of Alabama at Birmingham colleagues show, for the first time, how HIF1α in T cells is key for induction ...

Conversely, stabilization of HIF1α by knocking out a negative regulator of HIF1α increased IFN-γ under hypoxic conditions. With regard to defense against cancer, the researchers found that ...

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their ...

HIF1α identified as key regulator that induces cancer-killing ability of hypoxic T cells, playing a role in ICB resistance.

Conversely, stabilization of HIF1α by knocking out a negative regulator of HIF1α increased IFN-γ under hypoxic conditions. With regard to defense against cancer, the researchers found that ...