The discovery that RIPK1 deficiency sensitizes the liver to acute injury and hepatocyte apoptosis is based on convincing evidence, highlighting the importance of RIPK1 in maintaining liver homeostasis ...

An immortalized primary human hepatocyte cell line (HHL) was used to evaluate the effect of sTWEAK on triglyceride accumulation. Because of the burden of NAFLD in obesity, its association with ...

Through the use of hepatocyte-specific Ripk1-deficient mice (Ripk1Δhep), the authors embarked on an examination of the consequences of Ripk1 deficiency in hepatocytes under fasting conditions. They ...

Objective Lipotoxic hepatocyte injury is a primary event in non-alcoholic steatohepatitis (NASH), but the mechanisms of lipotoxicity are not fully defined. Sphingolipids and free cholesterol (FC) ...

However, the roles of SphK2 in the hepatic lipid metabolism of NAFLD have not been elucidated. Methods Wild-type (SphK2-Flox), hepatocyte-specific SphK2 knockout (SphK2-HKO) mice and SphK2 ...

Background and aims The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a ...

How cellular metabolism contributes to liver regeneration remains poorly understood. This study identifies sodium-dependent dicarboxylate transporter 1 (SLC13A2, NaDC1) as facilitator of liver repair, ...

A recent publication describes how Gd-EOB-DTPA-enhanced Magnetic Resonance Imaging reflects the co-activation of β-catenin and Hepatocyte Nuclear Factor 4α in hepatocellular carcinoma PubMed. Eur ...

The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in organ development. Although ...