The drug also enhances lysosome biogenesis in animal models and patient-derived fibroblasts. In TPP1-deficient animals, PLX-200 is neuroprotective and prolongs lifespan. PLX-200 was originally ...

Researchers hope to plan clinical trials of 5-fluorouracil with drugs that would enhance its RNA-damaging effects and kill ...

Doctors have long believed the cancer drug 5-fluorouracil works by damaging the building blocks of DNA, but researchers have now found that in certain cancers, it kills cells by interfering with RNA ...

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism of the ULK ...

Since the 1950s, a chemotherapy drug known as 5-fluorouracil has been used to treat many types of cancer, including blood ...

including lysosome activity, and help delay age-related diseases and improve healthspan." More information: Bo Lv et al, A ...

Study reveals the drug, 5-fluorouracil, acts differently in different types of cancer — a finding that could help researchers design better drug combinations.

A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote ...

Biogenesis of America, a Miami wellness clinic fueled by a cocaine-addicted biochemist who introduced himself as "Dr. T," outed some of the nation's biggest stars as PED users; still others have ...