The drug also enhances lysosome biogenesis in animal models and patient-derived fibroblasts. In TPP1-deficient animals, PLX-200 is neuroprotective and prolongs lifespan. PLX-200 was originally ...

We now introduce an algorithm called Root Causal Strength using Perturbations (RCSP) that discovers the surrogate ancestors of each variable using Perturb-seq and then computes the RCS of each ...

Researchers hope to plan clinical trials of 5-fluorouracil with drugs that would enhance its RNA-damaging effects and kill ...

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism of the ULK ...

Doctors have long believed the cancer drug 5-fluorouracil works by damaging the building blocks of DNA, but researchers have now found that in certain cancers, it kills cells by interfering with RNA ...

Autophagosome biogenesis is impaired in Rett syndrome, a complex neurodevelopmental disorder caused by loss of function ...

including lysosome activity, and help delay age-related diseases and improve healthspan." More information: Bo Lv et al, A ...

Since the 1950s, a chemotherapy drug known as 5-fluorouracil has been used to treat many types of cancer, including blood ...

“Lysosomes are organelles that are involved in autophagy, a cellular process that cleans up damaged material, almost like a housekeeping or recycling system,” said Tan. “In response to STING ...

Biogenesis of America, a Miami wellness clinic fueled by a cocaine-addicted biochemist who introduced himself as "Dr. T," outed some of the nation's biggest stars as PED users; still others have ...