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Acute respiratory distress syndrome (ARDS) is a neutrophil-dominant disorder with no effective pharmacological therapies. While the cyclin-dependent kinase inhibitor AT7519 induces neutrophil ...

The central components of this system are the cyclin-dependent kinases (Cdks), the activities of which oscillate during the cell cycle in response to changes in their association with regulatory ...

Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China ...

This valuable study uses zebrafish as a model to reveal a role for the cell cycle protein kinase CDK2 as a negative regulator of type I interferon signaling. The evidence supporting the authors' ...

据外媒报道，在2025年美国拉斯维加斯消费电子展（CES 2025）上，Human Insight AI 先进供应商Smart Eye展示其全面的 人工智能 （AI）解决方案，以提高座舱内的安全性、个性化和车辆智能化。

Signaling via phosphorylation-regulated protein-protein interactions often involves flexible or unstructured proteins. Detailed biophysical and computational studies on one such interaction reveal ...

In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that provides stability ...

Cancer is the second greatest cause of mortality worldwide. According to estimates from the World Health Organization, there were approximately 19 million new cancer cases globally in 2020, resulting ...

Background Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and associated damaging products in the airway. Delayed neutrophil apoptosis is described in CF although it is ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...