Since the application of molecular biology in cancer biology, lung cancer research has classically focused on molecular drivers of disease. One such pathway, the hypoxic response pathway, is ...

Expression of Negative Regulators of the Hypoxic Response Pathway is Altered in NSCLC Given that HIF1 and HIF2 have such wide ranging transcriptional targets; it is essential that the hypoxic ...

de la Calle-Fabregat, C., et al. (2024) NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the ...

HIF1α identified as key regulator that induces cancer-killing ability of hypoxic T cells, playing a role in ICB resistance.

More information: Carlos de la Calle-Fabregat et al, NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment, Science ...

The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen ... “However, it has been unknown, under hypoxia, whether and how HIF1α regulates IFN-γ induction and glycolysis ...

In this talk, I will discuss the metabolic constraints imposed by the tumor microenvironment and how this may impact T cell responses against tumors. Specific emphasis will be placed on the condition ...

The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen ... how HIF1α in T cells is key for induction of interferon gamma, or IFN-γ, in that hypoxic environment. The cytokine ...

Yet any potential intervention has to take place under unusual conditions -- the cancer microenvironment nearly ... or IFN-γ, in that hypoxic environment. The cytokine IFN-γ is known to be ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...