This manuscript offers valuable insights by identifying two distinct liver cancer subtypes through multi-omics integration and developing a robust prognostic model, validated across various datasets, ...

Despite recent therapeutic breakthroughs, cancer patients continue to face high recurrence and mortality rates due to treatment resistance. Cancer stem cells (CSCs), a subpopulation with self-renewal ...

HIF1α identified as key regulator that induces cancer-killing ability of hypoxic T cells, playing a role in ICB resistance.

Patients with liver tumors that meet the following may be candidates: The tumor is less than 4 centimeters in size Have three or fewer tumors The tumor is in a favorable location for treatment Talk to ...

Breast cancer cells exhibit organotropism during metastasis, showing preferential homing to certain organs such as bone, lung, liver, and brain. One potential explanation for this organotropic ...

The tumor microenvironment (TME) refers to the cells ... Immune checkpoint inhibitors rescue T cell activity by blocking surface proteins responsible for dysregulation. In addition, the TME is highly ...

Lin said that in a hypoxic tumor microenvironment, cancer cells secrete hydrogen sulfide and send a signal to the tetrameric protein pyruvate kinase (PKM2), causing it to break down into smaller ...

HSINCHU, Taiwan, Dec. 19, 2024 (GLOBE NEWSWIRE) -- Associate professors Kai-Ti Lin of the Institute of Biotechnology and Hui-Chun Cheng of the Institute of Bioinformatics and Structural Biology at ...

The significant role of tumor microenvironment (TME) in the initiation ... with the aim of identifying potential targets for immunotherapy. In hypoxic TME, hypoxia-relative genes facilitate cell death ...

Cysts and tumors are both types of lumps commonly found in the body. While some cysts can lead to cancer, these are typically benign. Tumors, however, can be either benign or malignant.

Yet any potential intervention has to take place under unusual conditions — the cancer microenvironment nearly devoid of oxygen due to fast growth ... how HIF1a in T cells is key for induction of ...