Since the application of molecular biology in cancer biology, lung cancer research has classically focused on molecular drivers of disease. One such pathway, the hypoxic response pathway, is ...

Hypoxia contributes to cancer resistance to both standard therapies and immunotherapy. This work demonstrates that tumor ...

The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen ... “However, it has been unknown, under hypoxia, whether and how HIF1α regulates IFN-γ induction and glycolysis ...

HIF1α identified as key regulator that induces cancer-killing ability of hypoxic T cells, playing a role in ICB resistance.

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders ...

The tumor microenvironment (TME) refers to the cells ... In addition, the TME is highly hypoxic or lacks oxygen, which not only disrupts T cell activity, but also promotes tumor growth. Cancer ...

Expression of Negative Regulators of the Hypoxic Response Pathway is Altered in NSCLC Given that HIF1 and HIF2 have such wide ranging transcriptional targets; it is essential that the hypoxic ...

Yet any potential intervention has to take place under unusual conditions -- the cancer microenvironment nearly ... or IFN-γ, in that hypoxic environment. The cytokine IFN-γ is known to be ...

Yet any potential intervention has to take place under unusual conditions—the cancer microenvironment nearly ... or IFN-γ, in that hypoxic environment. The cytokine IFN-γ is known to be ...

The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen ... how HIF1α in T cells is key for induction of interferon gamma, or IFN-γ, in that hypoxic environment. The cytokine ...