One such pathway, the hypoxic response pathway, is activated by reduced local oxygen concentrations at the tumor site. Hypoxia-driven gene and protein changes enhance epithelial-to-mesenchymal ...

However, the study also noted that muscle oxygenation was better maintained in hypoxia than in the brain, suggesting that different tissues may respond uniquely to hypoxic conditions[2].

The pathophysiology of residual sleepiness in treated obstructive sleep apnoea (OSA) remains poorly understood. Animal models ...

Hypoxia is a common feature of solid tumors that has previously been linked to resistance to radiotherapy and chemotherapy, and more recently to immunotherapy. In particular, hypoxic tumors exclude T ...

Brain injury resulting from hypoxia (oxygen deprivation) or ischemia (restricted blood flow) represents a major challenge in medical research and clinical ...

Long term adaption to a hypoxic insult is likely to require significant modification of chromatin structure in order to maintain the fibrotic phenotype. Epigenetic modifications may play an important ...

Hypoxic biomarkers included oxygen saturation (SpO2), RBC indicators and the hypoxia-inducible factor 1 (HIF-1) signaling pathway. Carotid-femoral pulse wave velocity (cfPWV), a marker of arterial ...

SeaTrac has used its SP-48 uncrewed surface vehicle (USV) to map potential hypoxic zones in the U.S. Gulf of Mexico as part ...

Puget Sound might be sheltered from feeling many strong winds directly, but it’s not immune to their ripple effects. For ...

DMOG (HIF1α activator), was used in these experiments to mimic the effect of hypoxia as the Seahorse Analyzer cannot be placed in a hypoxic chamber. Four baseline OCR and ECAR measurements were ...