Aging involves gradual functional decline across various biological systems, including impaired cellular mechanisms such as ...

However, excessive or uncontrolled neuroinflammation may damage neurons and exacerbate the pathologies in neurological disorders. Microglia are highly dynamic cells, dependent on energy supply from ...

The mitochondria act as the energy factories of our cells, creating ATP that drives our bodily functions. Inefficiencies in mitochondrial function have been associated with a variety of health ...

The mitochondrial genome is the full genetic complement of a mitochondrion. Mitochondrial DNA is only a small portion of the total DNA of a eukaryotic cell and in most species is solely inherited ...

A SIRT6 activator reduced plaque burden in mice. The AD connection? SIRT6 deacetylates three adjacent lysines in amyloid precursor protein, and this post-translational modification offers APP up to ...

Attribution (BY): Credit must be given to the creator. The 26S proteasome degrades the majority of cellular proteins and affects all aspects of cellular life. Therefore, the 26S proteasome abundance, ...

This cover highlights the article ZBTB48 is a priming factor regulating B-cell-specific CIITA expression by Grishma Rane, Dennis Kappei and colleagues. The study identifies how ZBTB48, represented as ...

The MRC Protein Phosphorylation and Ubiquitylation Unit (PPU) is a major research centre that focuses on the understanding of the biological roles of phosphorylation and ubiquitylation and how ...

It is well known that mitochondrial damage (MD) is both the major contributor to oxidative stress (OS) (the condition arising from unbalance between production and removal of reactive oxygen species) ...