It appears that, in addition to inducing cell death, anthracyclines also inhibit protein phosphatase 1, which triggers exposure of calreticulin. Inhibition of protein phosphatase 1 by other drugs ...

In the last decade, immune checkpoint blockade (ICB) has revolutionized the standard of treatment for solid tumors. Despite success in several immunogenic tumor types evidenced by improved survival, ...

From the Center for Systems Biology (W.C.P., M.N., F.K.S.), Massachusetts General Hospital and Harvard Medical School, Boston. From the Center for Systems Biology (W ...