衰老作为不可逆转的自然规律，其背后的生物学机制远比所见的表象要复杂。深入理解细胞衰老的机制及其对全身健康的影响，对于衰老研究至关重要。细胞衰老与多种器官系统的发病机制相关，衰老血液中的因子可驱动众多组织的衰老和炎症激活，但促衰老循环因子的组织和细胞特异性来源尚未明确。近些年来，随着研究的深入，越来越多的潜在抗衰老药物被发现。这时另一个亟需解决的问题出现了，那就是能够准确表征衰老的生物标志物。目前， ...

Ki-67 staining, a scratch experiment, real-time PCR, and Western blotting were used to explore the effect of the Th17 cell supernatant on keloid fibroblasts. Results: Our findings revealed the ...

Activation of MAPK pathway drives significant increases in CCL5 secretion by tumor cells, thereby impacting the abundance of Treg cells (71). Conversely, the CCL5/CCR5 axis can also activate the ...

Activated pDCs promote generation of both Th1/Th17 cells [46,76,87,92 ... TNF-α and chemokines CCL3, CCL4 and CCL5 [90], as well as inhibiting TLR9 processing necessary for TLR9-mediated ...