I used meta-cancer data of PanCanAtlas. This project assemble information from 10,824 tumor ... I reconstruct phylogentic trees using the clonal sequences (plus reference) with RAxML-ng. Both rooted ...

Despite advancements in cancer therapy, treatment resistance and disease recurrence remain formidable ... Furthermore, Tumor evolution, driven by the dynamic interplay between clonal selection, ...

Clonal hematopoiesis (CH) has been associated with a variety of adverse outcomes, most notably hematologic malignancy and ischemic cardiovascular disease. A series of recent studies also suggest that ...

The following figure demonstrates the reanalysis of a relapse acute myeloid leukemia case (AML1) published in Ding et al., Nature (2012). Top panel shows the original published fishplot, and the ...

Methods The authors fitted the two-stage clonal expansion model model to three occupational cohort studies: (1) a cohort of textile workers exposed to asbestos and followed for lung cancer mortality; ...

How such premalignancies contribute to the development of GA is, however, poorly understood. Methods In this study, the extent and clonal complexity in IM tissue from patients without gastric cancer ...

Emily Schwenger…Ulrich Steidl Blood Cancer Discovery May 2021. Toward More Complete Prognostication for Patients with Clonal Hematopoiesis Barbara Spitzer…Ross L. Levine Blood Cancer Discovery May ...