Enzymes catalyze nearly all of the chemical reactions that occur in biological systems. Enzymes are generally proteins but also include catalytic DNA and catalytic RNA. As effective biological ...

Ubiquitylation is the post-translational modification process by which ubiquitin is attached via an isopeptide bond to lysine residues on a protein. Ubiquitylation consists of three steps ...

(NASDAQ: CDXS), a leading provider of enzymatic solutions for efficient and scalable therapeutics manufacturing, today announced the appointment of Christos Richards to the Company’s Board of ...

Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to ...

The results revealed that antagonism between the guidance molecule Netrin-1 “pushing” developed neurons out of the germinal zone and the ubiquitin ligase Siah2 “pulling” undeveloped cells ...

The event will be webcast live and may be accessed via a link in the Investors section of the Nurix website. The archived webcast will be available for 30 days after the event. About Nurix ...

Thus, its activation represents a therapeutic strategy to combat obesity. Here, we demonstrate that levels of F-box and WD repeat domain-containing 7 (FBXW7), an E3 ubiquitin protein ligase, ...

Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China Institute of Integrated Bioinfomedicine and Translational Science (IBTS), ...

The protein ligase Connectase can be used to fuse proteins to small molecules ... The reaction requires short incubation times with small amounts of enzyme and is effective even at low substrate ...

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, Institute of Developmental Biology and Regenerative Medicine, College of Chemistry and ...

This cover highlights the article ZBTB48 is a priming factor regulating B-cell-specific CIITA expression by Grishma Rane, Dennis Kappei and colleagues. The study identifies how ZBTB48, represented as ...