The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Lipid nanoparticles (LNPs) represent a highly promising ...

Lipid nanoparticles (LNPs) are primed to revolutionize the development of nucleic acid therapies. The trusted lipid experts at Cayman Chemical provide industry-leading solutions for every stage of LNP ...

We used lipid nanoparticles to deliver mRNA and siRNA to human PCa cells to evaluate our technique's ability to both restore the lost PTEN and silence the overexpressed AR. Our strategy could also ...

The recent success of the mRNA-LNP vaccines fueled biopharma to explore lipid-based nanoparticles for advanced drug delivery. The industry is now poised to exploit the full therapeutic potential ...

Get Instant Summarized Text (Gist) Lipid nanoparticles encapsulating mRNA have been successfully delivered to the intestines, bypassing the liver, by altering the lipid composition. This method ...

However, recent research has raised concerns about the immunogenicity of PEG, particularly in the context of COVID-19 vaccines that utilize lipid nanoparticles ... the use of PEGylated therapeutics.

Consists of cationic lipid AtuFECT01, neutral helper lipid 1,2-diphytanoyl-sn-glycero-3-phosphoethanolamine, and PEGylated lipid ... Intravenous; LNP: Lipid nanoparticle; TTR: Transthyretin.

We used lipid nanoparticles to deliver mRNA and siRNA to human PCa cells to evaluate our technique’s ability to both restore the lost PTEN and silence the overexpressed AR. Our strategy could ...

A new class of lipids improve the rates at which lipid nanoparticles (LNPs) successfully deliver RNA therapeutics and gene editing tools, promising to increase their effectiveness of such treatments.