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郑刚教授:吸烟与动脉粥样硬化性心血管疾病(下篇)
吸烟对心血管健康的有害影响,特别是动脉粥样硬化和血栓形成,已经得到了很好的证实,更详细的机制也在不断出现。作为吸烟不良影响的基本病理生理学,内皮功能障碍、炎症和血栓形成被认为尤为重要。香烟烟雾诱导内皮功能障碍,导致血管扩张和止血调节受损。导致内皮功能障碍的因素包括一氧化氮生物利用度降低、超氧阴离子水平升高和内皮素释放。血管壁的慢性炎症是吸烟诱导动脉粥样硬化的核心发病机制。吸烟会全身性升高炎症标志物 ...
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