Tumour heterogeneity describes the observation that different tumour cells can show distinct morphological and phenotypic profiles, including cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. [1]

2017年11月8日 · In this Review, the authors describe the role of tumour heterogeneity in the development of acquired resistance, potential treatment strategies that take into account the heterogeneity of...

In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH …

We review experimental evidence for the existence of both intra-tumor clonal heterogeneity as well as frequent evolutionary divergence between primary tumors and metastatic outgrowths. Furthermore, we discuss potential biological and clinical implications of intra-tumor clonal heterogeneity. Keywords: diversity, selection, evolution. 1.

Tumor heterogeneity can be characterized by the uneven distribution of tumor cell subsets of other genes between and within the disease site (spatial heterogeneity) or the time change of cancer cell molecular composition (temporal heterogeneity).

2014年7月2日 · At Memorial Sloan Kettering and at other research centers around the world, the push is on to characterize the molecular variations between tumors — known as inter-tumor heterogeneity — and offer individualized treatments to more patients.

During the course of disease, cancers generally become more heterogeneous. As a result of this heterogeneity, the bulk tumour might include a diverse collection of cells harbouring distinct molecular signatures with differential levels of sensitivity to treatment.

2021年8月9日 · Tumors are spatially organized heterogeneous ecosystems: at the cellular level, they contain both cancer and stromal cell populations; at the genetic level, they are composed of genetically divergent tumor clones; and at the phenotypic level, cells within different microenvironmental niches acquire distinct phenotypes.

2013年1月8日 · Intra-tumour heterogeneity is likely to have implications for cancer therapeutics and biomarker discovery, particularly in the era of targeted treatment, and evidence for a relationship...

2023年7月4日 · Bioengineering strategies provide toolsets with which to analyse and model individual parameters that contribute to disease heterogeneity and affect tumour development, progression and therapy...