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    https://en.wikipedia.org › wiki › Alkaline_phosphatase

    Alkaline phosphatase - Wikipedia

    • The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase) is a phosphatase with the physiological role of dephosphorylating compounds. The enzyme is found across a multitude of organisms, prokaryotes and eukaryotes alike, with the same general function, but in different structural forms suitable to the environment they function in. Alkaline phosphatas… 展开

    Bacterial

    In gram-negative bacteria, such as Escherichia coli, alkaline phosphatase is located in the periplasmic space, external to the … 展开

    Use in research

    By changing the amino acids of the wild-type alkaline phosphatase enzyme produced by Escherichia coli, a mutant alkaline phosphatase is created which not only has a 36-fold increase in enzyme activity, but also … 展开

    Human

    In humans, alkaline phosphatase is present in all tissues throughout the body, but is particularly concentrated in the liver, bile duct, kidney, bone, intestinal mucosa and placenta. In the serum, two types of alkaline phosphatase … 展开

    Further reading

    • Coleman JE (1992). "Structure and mechanism of alkaline phosphatase". Annual Review of Biophysics and Biomolecular Structure. 21: 441–83. doi:10.1146/annurev.bb.21.060192.002301. PMID… 展开

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