2022年10月12日 · CXCR6 is a receptor for the chemokine CXCL16, which exists as a membrane or soluble form. CXCR6 is a marker for resident memory T (T RM) cells that plays a role in immunosurveillance through their interaction with epithelial cells.

Here we report that intranasal immunization with adenovirus-85A induces expression of the chemokine receptor CXCR6 on lung CD8 T lymphocytes, which is maintained for at least 3 months. CXCR6-positive antigen-specific T cell numbers are increased among bronchoalveolar lavage-recoverable cells.

CXCR6 is a receptor for the chemokine CXCL16, which exists as a membrane or soluble form. CXCR6 is a marker for resident memory T (T RM) cells that plays a role in immunosurveillance through their interaction with epithelial cells.

2024年12月24日 · CXCR6 (C-X-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CXCR6 include Type 1 Diabetes Mellitus 22 and Sarcoidosis 1. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Intravital imaging reveals how the chemokine receptor CXCR6 positions CD8+ cytotoxic T cells in a distinct perivascular niche of the tumor stroma that is populated by CCR7+ dendritic cells expressing the CXCR6-ligand CXCL16 and trans-presenting the cytokine IL-15.

2023年9月7日 · Here we identify brain-resident CD8 + T cells that coexpress CXCR6 and PD-1 and are in proximity to plaque-associated microglia in human and mouse AD brains. We also establish that CD8 + T cells...

2025年1月4日 · CXCR6 expression is down-regulated, independent of CCR5 or CD69 expression and of cytokine induction, by T cell activation signals that involve predominantly the Ca(2+)-dependent calcineurin pathway. CXCR6 was expressed more frequently on synovial T cells than in peripheral blood

2021年8月19日 · CXCR6 expression and IL-15 trans-presentation are critical for the survival and local expansion of effector-like CTLs in the tumor microenvironment to maximize their anti-tumor activity before progressing to irreversible dysfunction.

Indeed, recent progress of immunology strongly suggests that CXC chemokine receptor 6 (CXCR6, CD186) is such a kind of marker. Here, we review the emerging role of CXCR6 as a novel target for immunotherapy and discuss the underlying mechanism.

CXCR6 is a chemokine receptor expressed on a specific subset of T cells involved in inflammation, suggesting a role in T-cell migration to inflamed areas. AI generated definition based on: Trends in Pharmacological Sciences, 2006