Epoxide Hydrolase, a Fat New Target for Alzheimer’s Therapy?
2020年12月15日 · The scientists found more epoxide hydrolase in brain tissue from people with AD and 5xFAD mice than in controls, corresponding to fewer epoxy fatty acids in the mice. Long-term treatment with an inhibitor curbed the hydrolase and …
Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ ...
2023年8月2日 · Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease. Neurotherapeutics. 2020 Jun 2; PubMed. Martini RP, Siler D, Cetas J, Alkayed NJ, Allen E, Treggiari MM. A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage.
Could Inhibiting a Liver Enzyme Ameliorate Alzheimer’s
2023年8月2日 · But what if targeting a peripheral enzyme could do the job? In the June 26 Neuron online, researchers led by Xin-Hong Zhu at Shenzhen University, China, reported that inhibiting a liver enzyme, soluble epoxide hydrolase (sEH), boosted the amount of protective epoxy fatty acids, particularly 14,15-epoxyeicosatrienoic acid, in the blood of mice.
TMEM175 Maintains Lysosome pH by Pushing Out Protons
2022年6月23日 · The work of this paper and others suggests that the function of each of the proteins encoded by these genes are intimately connected. For instance, glucocerebrosidase (GCase), the protein product of GBA1, exhibits optimal hydrolase activity at a pH of 4.7-5.5 (Karatas et al., 2020).
Genetic deletion of soluble epoxide hydrolase delays the …
Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer's disease. J Neuroinflammation. 2019 Dec 17;16(1):267. PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.
Soluble epoxide hydrolase: a next-generation drug target for …
Soluble epoxide hydrolase: a next-generation drug target for Alzheimer's disease and related dementias. Neural Regen Res. 2025 Sep 1;20(9):2585-2586. Epub 2024 Sep 6 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.
Fatty acid amide hydrolase gene inactivation induces hetero …
Fatty acid amide hydrolase gene inactivation induces hetero-cellular potentiation of microglial function in the 5xFAD mouse model of Alzheimer's disease. Glia. 2025 Feb;73(2):352-367. Epub 2024 Oct 30 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or ...
New Therapeutic Strategy—Mimic the ApoE Christchurch Mutation?
2023年10月24日 · Further, a recent study showed that inhibition of liver enzyme soluble epoxide hydrolase drives a subsequent increase of 14,15-epoxyeicosatrienoic acid in the blood and into the brain, release of ApoE by astrocytes, and activation of microglia that reduces Aβ plaque pathology and improves cognitive function (Wu et al., 2023).
Epigenetic regulation of fatty acid amide hydrolase in Alzheimer ...
Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease. PLoS One. 2012;7(6):e39186. PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.
APOE Christchurch-mimetic therapeutic antibody reduces APOE …
2023年10月30日 · Further, a recent study showed that inhibition of liver enzyme soluble epoxide hydrolase drives a subsequent increase of 14,15-epoxyeicosatrienoic acid in the blood and into the brain, release of ApoE by astrocytes, and activation of microglia that reduces Aβ plaque pathology and improves cognitive function (Wu et al., 2023).