Isoferulic acid is a ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 4 and 3 respectively on the phenyl ring. It has a role as a metabolite, a biomarker and an antioxidant.

Here, we identified isoferulic acid (IFA), a natural phenolic acid compound widely present in traditional herbal medicines, as a potent broad-spectrum K. pneumoniae capsule inhibitor that suppresses capsule polysaccharide synthesis by increasing the energy status of bacteria.

More recent studies suggest that black cohosh, contrary to prior alleged identification of isoflavones in the plant, does not contain isoflavones (e.g., biochanin A, formononetin). Kaempferol has been found in extracts of the leaf.

Isoferulic acid (IFA), also known as 3- (3-hydroxy-4-methoxyphenyl)-2-propenoic acid, is a natural compound extracted from Cimicifuga heracleifolia (CH), which is frequently used in traditional medicine in Asian countries for treating inflammatory diseases and specific cancers (9, 10).

2020年9月15日 · These are compounds containing an cinnamic acid where the benzene ring is hydroxylated. Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package. Unlock 175K+ …

2025年1月10日 · Isoferulic acid (IFA) is a phenolic compound that has strong antioxidant, anti-inflammatory, and hypoglycemic effects. Researches and our previous study showed the potential anti-diabetic capacity and anti- oxidative stress damage targeting podocytes of IFA.

Isoferulic acid is a monomeric derivative described in the context of Salvia constituents in the provided text. You might find these chapters and articles relevant to this topic. Thomas F. DeRosa, in Significant Pharmaceuticals Reported in US Patents, 2007.

2013年5月30日 · Therefore, IFA might be a new promising anti-glycation agent for the prevention of diabetic complications via inhibition of AGEs formation and oxidation-dependent protein damage. 1. Introduction. Protein glycation is a non-enzymatic reaction between the carbonyl group of a reducing sugar and the free amino group of a protein.

Ferulic acid (Fig. 28.10), the 3-methyl ester of caffeic acid, is also widely distributed among many plants and it inhibits TNF-α and macrophage inflammatory protein-2 production, while isoferulic acid potently inhibits COX expression; and both ferulic and isoferulic acids inhibit the production of IL-8 in cells in response to the influenza ...

Isoferulic acid (3-hydroxy-4-methoxycinnamic acid, IFA), the isomer of ferulic acid (4-hydroxy-3-methoxycinnamic acid), is a rare phenolic acid occurring in Rhizoma Cimicifugae. Unlike ferulic acid, which has been well investigated, the antioxidant activity of IFA has not been measured.