Peptidoglycan or murein is a unique large macromolecule, a polysaccharide, consisting of sugars and amino acids that forms a mesh-like layer (sacculus) that surrounds the bacterial cytoplasmic membrane. [1]

2017年4月28日 · Peptidoglycan, also called murein, is a polymer that makes up the cell wall of most bacteria. It is made up of sugars and amino acids, and when many molecules of peptidoglycan joined together, they form an orderly crystal lattice structure.

Peptidoglycan is a defining feature of the bacterial cell wall. Initially identified as a target of the revolutionary beta-lactam antibiotics, peptidoglycan has become a subject of much interest for its biology, its potential for the discovery of novel antibiotic targets, and its role in infection. …

Peptidoglycan is the outermost cell wall layer of gram-positive bacteria. In gram-negative bacteria, additional layers are present outside this rigid layer, called lipopolysaccharide. The peptidoglycan layer is much thicker in gram-positive than in gram-negative bacteria.

Peptidoglycan is a defining feature of the bacterial cell wall. Initially identified as a target of the revolutionary beta-lactam antibiotics, peptidoglycan has become a subject of much interest for its biology, its potential for the discovery of novel antibiotic targets, and its role in infection.

2025年1月12日 · Peptidoglycan’s robust network plays a central role in ensuring this integrity, as it provides the necessary support to withstand mechanical stress. The strength of this meshwork is a direct consequence of its intricate architecture, which balances rigidity and flexibility to accommodate cellular needs.

2023年8月31日 · The peptidoglycan cell wall surrounds the cytoplasmic membrane and prevents osmotic lysis. Peptidoglycan is composed of interlocking chains of building blocks called peptidoglycan monomers.

2024年10月7日 · Peptidoglycan is a complex, mesh-like polymer that forms a protective layer around bacterial cells. Its structure is primarily composed of glycan chains, which are long strands of alternating N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) residues.

2024年10月7日 · Peptidoglycan is a critical component in the cell walls of Gram-positive bacteria, serving as both structural support and a defensive barrier. Its significance cannot be understated, given its role in maintaining cellular integrity and shape under various environmental conditions.

The peptidoglycan (murein) sacculus is a unique and essential structural element in the cell wall of most bacteria. Made of glycan strands cross-linked by short peptides, the sacculus forms a closed, bag-shaped structure surrounding the cytoplasmic membrane.