Caspase - Wikipedia
Caspase-1 therefore plays a fundamental role in the innate immune system. The enzyme is responsible for processing cytokines such as pro-ILβ and pro-IL18, as well as secreting them. [21] Caspase-4 and -5 in humans, and Caspase-11 in mice have a unique role as a receptor, whereby it binds to LPS, a molecule abundant in gram negative bacteria ...
Caspase Functions in Cell Death and Disease - PMC - PubMed …
Caspases are key regulators of apoptosis and inflammation. Insufficient caspase activation can promote tumorigenesis or infection; hyperactivation can promote neurodegeneration or inflammatory conditions.
Caspases in cell death, inflammation and disease - PMC
Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in ...
Caspase - an overview | ScienceDirect Topics
Caspase refers to a family of cysteine proteases that are Ced-3 homologues and play a crucial role in apoptosis. They are initially produced as inactive proforms and become active after being cleaved. Caspase-3, having the highest similarity to Ced-3, is considered the main effector in apoptosis and cleaves multiple apoptosis substrates.
Caspases in Cell Death, Inflammation, and Disease - Cell Press
Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years.
Caspbase
Welcome to the CaspBase – the Caspase Sequence Database. Caspases (cysteinyl aspartate-specific proteases) are an ancient class of enzymes that maintain cellular homeostasis by controlling the cell death program, apoptosis. They also are critical to cell development when activated at low levels.
Caspases in Cell Death, Inflammation, and Disease - PubMed
2019年6月18日 · Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years.
A Primer on Caspase Mechanisms - PMC - PubMed Central (PMC)
Caspase-11 was the first enzyme discovered to participate in a non-canonical or non-caspase-1 mediated inflammasome as a response to gram-negative bacteria. This then led to the discovery of caspase-11’s proposed role as direct sensor of intracellular LPS from gram-negative bacteria during macrophage-mediated inflammatory responses [ 60 , 61 ].
Caspases and their substrates | Cell Death & Differentiation - Nature
2017年5月12日 · The human caspase family is divided into three main groups, primarily based on sequence similarity and biological function. 15 Group I comprises the inflammatory caspases-1, -4, and -5...
Home - CaspSites
A collection of human caspase substrates identified in apoptotic cells and caspase-treated lysates