Lentivirus (LV) is an enveloped single-stranded RNA virus of the Retrovirdae family that binds host cell receptors and results in ejection of transgene material into the cytoplasm.

Acute infection with human lentiviruses can appear as non-specific “flu-like” and “mononucleosislike” symptoms, including myalgia, arthralgia, diarrhea, nausea, vomiting, headache, hepatosplenomegaly, weight loss and neurological symptoms.

2023年7月20日 · Lentivirus represents a genus of slow viruses with long incubation period (months, even years) and a propensity to induce a wide range of pathologies in different animal species.

Lentivirus is based on the human immunodeficiency virus and has an 8-kb carrying capacity. Because the DNA integrates into the genome, lentivirus delivery leads to long-term expression.

Lentivirus (lente-, latin for “slow”) is a group of retroviruses characterized for a long incubation period. They are classified into five serogroups according to the vertebrate hosts they infect: bovine, equine, feline, ovine/caprine and primate.

Lentiviruses are associated with a variety of diseases, including immunodeficiencies, neurological disorders and arthritis, whereas others appear non-pathogenic. No oncogene-containing member of this genus has been isolated. Some groups have cross-reactive Gag antigens (e.g. ovine, caprine and feline lentiviruses).

GENETICS AND LIFE CYCLE OF LENTIVIRUSES The lentiviruses are a subgroup of retroviruses associated with slow chronic diseases in humans and animals. The best-characterized lentivirus is the human immunodeficiency virus type 1 (HIV-1), which causes acquired immunodeficiency syndrome in humans.

Most lentiviral vectors (LVVs) are derived from the human immunodeficiency virus (HIV) type 1 and retain the ability to integrate into the genome of infected cells. 1 Integrating DNA into the genome of host cells is a powerful technique that allows scientists to manipulate genes and gene expression. 2, 3 This technology is used both at the labor...

Lentiviruses are a subfamily of retroviruses that are characterized by long incubation periods between infection of the host and the manifestation of clinical disease. Human immunodeficiency virus type 1, the causative agent of AIDS, is the most widely studied lentivirus.

Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene therapy.