The degree of sensitivity that is achieved by radiotracer methods rests on the specific activity (SA) of the radioactive sample. The SA is a measure of the amount of radioactivity per mass (radioactive + nonradioactive) and, for radiotracer studies, is commonly expressed in proportional units (Ci/mmol) [11]. In this article, it is generally ...

2024年11月26日 · Radiotracer uptake refers to the absorption of a radioactive substance (radiotracer) by specific tissues or organs in the body. This process allows imaging techniques like PET scans to visualize ...

2022年5月1日 · Besides its application as perfusion tracer, [13 N]ammonia was used as metabolic tracer, especially in investigation of hepatic encephalopathy. 26 Even though [13 N]ammonia is by far the most wildly applied 13 N labelled radiotracer, synthesis of more complex radiotracers like [13 N]Nifedipine 27 or the amino acid 13 N-L-glutamate 28 is reported.

1984年1月1日 · However, a rationale for radiotracer design based on specific biochemical targets has evolved concurrently with the development of positron emission tomography (PET) and single photon emission tomography (SPECT).13,71 These developments, and improved imaging provided by the complementary techniques of computed tomography and nuclear magnetic ...

Radiotracer technology deals with tools to prepare adequate radiotracers, to inject them in a proper way, to measure the radioactivity in the field or through sampling in the laboratory, as well as to obtain reliable experimental data, to treat them with specific software and to extract maximum of results about the process in investigation.

2019年3月15日 · [18 F]Fluortriopride (Fig. 4) is a radiotracer with great selectivity for dopamine D 3-receptor (D3R). Its selectivity for D 3 R is 160 times greater than D 2 R. It is considered a potential radiotracer for the study of neuropsychiatric disorders such as Parkinson disease.

2025年1月15日 · (C) Quantitative analysis of radiotracer uptake in PC3 xenograft tumors and (D) 22Rv1 xenograft tumors based on the PET imaging data. (E) PET imaging of (1), (2), and (3) in DU145 tumor-bearing mice. (F) Quantitative assessment of radiotracer uptake in DU145 xenograft tumors. PET imaging was performed at 90 min after injection.

2024年6月15日 · Radiotracer uptake refers to the absorption of a radioactive substance (radiotracer) by specific tissues or organs in the body. This process allows imaging techniques like PET scans to visualize ...

2025年1月5日 · Satisfactorily, [18 F]FA1 fulfilled critical requirements as a Tau radiotracer, demonstrating high specificity and selectivity for Tau, a clean off-target profile against Aβ plaques and monoamine oxidase B (MAO-B), and favorable in vivo brain kinetics, as confirmed by dynamic PET studies in rodents and non-human primates.

2023年12月1日 · At 90 min after radiotracer injection, 18 F-FAPTG uptake in bone, blood pool and pancreas decreased sharply, while the tumor uptake maintained at a steadily high level (5.19 ± 1.10% ID/g). 18 F-FAPTG displayed relatively rapid clearance through the kidneys, which indicated that the urinary system was the predominant excretion pathway for 18 F ...